RESEARCH
Publications
Article
Can social media predict micro constituency and macro election outcome? exploration, insights and reflections of digital political content diffusion using data science
Introduction:
There is a lack of both data and, more significantly, computational analyses of the linguistic behavior near an individual's final moments of life. The present study is aimed to reduce human bias and save time in psycholinguistic studies by providing data-backed insights.
Methods:
A novel machine learning based pipeline proposed, using elements of semantic similarity (BERT and transformers) and emotion extraction in collaboration, to analyze the final statements of death row inmates to understand the consistency in their verbal expression moments before their death. A new method of analysis was proposed in this study to explore the notions inherent in the statements. A large database of 466 final statements from death row inmates in Texas was utilized in this study. Manual notion analysis was validated by a computational method of notion inferencing.
Results:
Basic emotions of Anger and Fear majorly dominated the statements, constituting 54% of the whole, while 21% of all statements were of emotional states of Happiness and Serenity.
Discussion:
The outcomes of this study are expected to contribute to psychological analyses of humans, moments before death, and provide insights to criminology researchers to formulate better strategies of rehabilitation and debate the death penalty.Article
Simulation of nanocarrier-based targeted delivery of an antidepressant for major depressive disorder
Although Depression or Major Depressive Disorder (MDD) affects nearly 15% of the adult population, yet, common antidepressants that work through the monoamine hypothesis of depression are not effective against all types of MDD. The other hypothesis, blocking N-methyl D-aspartate (NMDA) receptors (NMDAR) with antagonists to promote antidepressant effects, is not very useful because of the adverse side effects of the NMDA antagonists. In this study, we have proposed a method involving the specific drug delivery of an antidepressant, using nanocarriers. The introduction of nanocarrier encapsulated potent NMDAR antagonist, R-ketamine, in the target neuronal environments of varying membrane potentials of the central nervous system was studied using in-silico coarse grain simulation of hollow spherical polypyrrole nanocarriers or increasing size. The membrane potential ruptures the nanocarrier and releases the drug R-ketamine, which has a high-binding affinity for NMDAR. Such coarse grain simulations are an interesting and emerging field of study and shed preliminary light on the theoretical behaviour of nanopharmaceuticals in vivo. The results of these in silico findings need to be validated with in vivo experimentation to develop an improved antidepressant delivery nanoformulation.
